Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR
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چکیده
منابع مشابه
Synthesis of Novel Anti-Inflammatory and Antimicrobial Agents via Ugi-4CR and its Evaluation
Article history: Received on: 03/02/2013 Revised on: 20/02/2013 Accepted on: 05/03/2013 Available online: 30/03/2013 An efficient and rapid synthesis of novel anti-inflammatory and antimicrobial agents using 4-aminoantipyrine, nicotinic acid, ethylisocyanoacetate and substituted aldehydes via Ugi four component reaction (Ugi-4CR) protocol under microwave irradiation in presence of Fluorite as a...
متن کاملInvestigation of the Passerini and Ugi reactions in β-lactam aldehydes. Synthetic applications.
Passerini (P-3CR) and Ugi (U-4CR) reactions were investigated in 4-oxoazetidine-2-carboxaldehydes, affording the corresponding Passerini and Ugi adducts with moderate diastereoselectivity in high yields. Fortunately, the obtained mixtures of isomers syn/anti were separated in most cases. The scope of both IMCRs has been studied using a variety of isocyanides, carboxylic acids and amines. Ugi ad...
متن کاملLibrary-to-Library Synthesis of Highly Substituted α-Aminomethyl Tetrazoles via Ugi Reaction
α-Aminomethyl tetrazoles, recently made accessible by an Ugi multicomponent reaction (MCR), were shown to be excellent starting materials for a further Ugi MCR, yielding substituted N-methyl-2-(((1-methyl-1H-tetrazol-5-yl)methyl)amino)acetamides having four points of diversity in a library-to-library approach. The scope and limitations of the two-step sequence was explored by conducting more th...
متن کاملAn efficient microwave-assisted synthesis of cotinine and iso-cotinine analogs from an Ugi-4CR approach.
A convenient base-mediated two-step synthesis of cotinine analogs and a one-pot base-free synthesis of iso-cotinine derivatives featuring an Ugi-4CR/cyclization protocol are reported. These approaches exploit the reactivity of the peptidyl position present in the Ugi adducts, allowing the facile construction of the γ-lactam core, as well as the introduction of a N-substituted methyl group into ...
متن کاملSynthesis of dihydrophenanthridines by a sequence of Ugi-4CR and palladium-catalyzed intramolecular C-H functionalization
BACKGROUND Small polyfunctionalized heterocyclic compounds play important roles in the drug discovery process and in the isolation and structural identification of biological macromolecules. It is expected that ready access to diverse sets of heterocycles can not only help improving the known biological and pharmacokinetic properties of drugs, but also assist the discovery of molecules that exh...
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ژورنال
عنوان ژورنال: ACS Combinatorial Science
سال: 2018
ISSN: 2156-8952,2156-8944
DOI: 10.1021/acscombsci.7b00145